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Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain
The Ras-guanyl nucleotide exchange factor RasGRP1 plays a critical role in T cell receptor-mediated Erk activation. Previous studies have emphasized the importance of RasGRP1 in the positive selection of thymocytes, activation of T cells, and control of autoimmunity. RasGRP1 consists of a number of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3373593/ https://ncbi.nlm.nih.gov/pubmed/22719950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038796 |
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