Regulation of RasGRP1 Function in T Cell Development and Activation by Its Unique Tail Domain

The Ras-guanyl nucleotide exchange factor RasGRP1 plays a critical role in T cell receptor-mediated Erk activation. Previous studies have emphasized the importance of RasGRP1 in the positive selection of thymocytes, activation of T cells, and control of autoimmunity. RasGRP1 consists of a number of...

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Autores principales: Fuller, Deirdre M., Zhu, Minghua, Song, Xiaohua, Ou-Yang, Chih-wen, Sullivan, Sarah A., Stone, James C., Zhang, Weiguo
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373593/
https://ncbi.nlm.nih.gov/pubmed/22719950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038796
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