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Clustering by Plasma Lipoprotein Profile Reveals Two Distinct Subgroups with Positive Lipid Response to Fenofibrate Therapy

Fibrates lower triglycerides and raise HDL cholesterol in dyslipidemic patients, but show heterogeneous treatment response. We used k-means clustering to identify three representative NMR lipoprotein profiles for 775 subjects from the GOLDN population, and study the response to fenofibrate in corres...

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書誌詳細
主要な著者: van Bochove, Kees, van Schalkwijk, Daniël B., Parnell, Laurence D., Lai, Chao-Qiang, Ordovás, José M., de Graaf, Albert A., van Ommen, Ben, Arnett, Donna K.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
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オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373573/
https://ncbi.nlm.nih.gov/pubmed/22719863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038072
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