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Clustering by Plasma Lipoprotein Profile Reveals Two Distinct Subgroups with Positive Lipid Response to Fenofibrate Therapy

Fibrates lower triglycerides and raise HDL cholesterol in dyslipidemic patients, but show heterogeneous treatment response. We used k-means clustering to identify three representative NMR lipoprotein profiles for 775 subjects from the GOLDN population, and study the response to fenofibrate in corres...

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Detalhes bibliográficos
Main Authors: van Bochove, Kees, van Schalkwijk, Daniël B., Parnell, Laurence D., Lai, Chao-Qiang, Ordovás, José M., de Graaf, Albert A., van Ommen, Ben, Arnett, Donna K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373573/
https://ncbi.nlm.nih.gov/pubmed/22719863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038072
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