F-actin polymerization and retrograde flow drive sustained PLCγ1 signaling during T cell activation

Activation of T cells by antigen-presenting cells involves assembly of signaling molecules into dynamic microclusters (MCs) within a specialized membrane domain termed the immunological synapse (IS). Actin and myosin IIA localize to the IS, and depletion of F-actin abrogates MC movement and T cell a...

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Main Authors: Babich, Alexander, Li, Shuixing, O'Connor, Roddy S., Milone, Michael C., Freedman, Bruce D., Burkhardt, Janis K.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2012
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373411/
https://ncbi.nlm.nih.gov/pubmed/22665519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201201018
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