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Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow

The Arp2/3 complex nucleates actin filaments to generate networks at the leading edge of motile cells. Nonmuscle myosin II produces contractile forces involved in driving actin network translocation. We inhibited the Arp2/3 complex and/or myosin II with small molecules to investigate their respectiv...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yang, Qing, Zhang, Xiao-Feng, Pollard, Thomas D., Forscher, Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384413/
https://ncbi.nlm.nih.gov/pubmed/22711700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201111052
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