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S-Glutathionylation of Cysteine 99 in the APE1 Protein Impairs Abasic Endonuclease Activity
Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is a central participant in the base excision repair pathway, exhibiting AP endonuclease activity that incises the DNA backbone 5′ to an abasic site. Besides its prominent role as a DNA repair enzyme, APE1 was separately identified as a protein...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3373313/ https://ncbi.nlm.nih.gov/pubmed/22024594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.023 |
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