Functions of the major abasic endonuclease (APE1) in cell viability and genotoxin resistance

DNA is susceptible to a range of chemical modifications, with one of the most frequent lesions being apurinic/apyrimidinic (AP) sites. AP sites arise due to damage-induced (e.g. alkylation) or spontaneous hydrolysis of the N-glycosidic bond that links the base to the sugar moiety of the phosphodiest...

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Vydáno v:Mutagenesis
Hlavní autoři: McNeill, Daniel R, Whitaker, Amy M, Stark, Wesley J, Illuzzi, Jennifer L, McKinnon, Peter J, Freudenthal, Bret D, Wilson, David M
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7016205/
https://ncbi.nlm.nih.gov/pubmed/31816044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/gez046
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