Functional Analysis of Novel Analogues of E3330 That Block the Redox Signaling Activity of the Multifunctional AP Endonuclease/Redox Signaling Enzyme APE1/Ref-1

APE1 is a multifunctional protein possessing DNA repair and redox activation of transcription factors. Blocking these functions leads to apoptosis, antiangiogenesis, cell-growth inhibition, and other effects, depending on which function is blocked. Because a selective inhibitor of the APE redox func...

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Autores principales: Kelley, Mark R., Luo, Meihua, Reed, April, Su, Dian, Delaplane, Sarah, Borch, Richard F., Nyland, Rodney L., Gross, Michael L., Georgiadis, Millie M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2011
Materias:
Original Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061197/
https://ncbi.nlm.nih.gov/pubmed/20874257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2010.3410
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