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S-Glutathionylation of Cysteine 99 in the APE1 Protein Impairs Abasic Endonuclease Activity

Human apurinic/apyrimidinic (AP) endonuclease 1 (APE1) is a central participant in the base excision repair pathway, exhibiting AP endonuclease activity that incises the DNA backbone 5′ to an abasic site. Besides its prominent role as a DNA repair enzyme, APE1 was separately identified as a protein...

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מידע ביבליוגרפי
Main Authors: Kim, Yun-Jeong, Kim, Daemyung, Illuzzi, Jennifer L., Delaplane, Sarah, Su, Dian, Bernier, Michel, Gross, Michael L., Georgiadis, Millie M., Wilson, David M.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2011
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373313/
https://ncbi.nlm.nih.gov/pubmed/22024594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.023
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