IL-18 Induces Emphysema and Airway and Vascular Remodeling via IFN-γ, IL-17A, and IL-13

Rationale: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation, alveolar destruction, and airway and vascular remodeling. However, the mechanisms that lead to these diverse alterations have not been defined. Objectives: We hypothesized that IL-18 plays a central rol...

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Main Authors: Kang, Min-Jong, Choi, Je-Min, Kim, Bo Hye, Lee, Chang-Min, Cho, Won-Kyung, Choe, Gina, Kim, Do-Hyun, Lee, Chun Geun, Elias, Jack A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3373071/
https://ncbi.nlm.nih.gov/pubmed/22383501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201108-1545OC
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