IL-2 and IL-18 Attenuation of Airway Hyperresponsiveness Requires STAT4, IFN-γ, and Natural Killer Cells

IL-18 is known to induce IFN-γ production, which is enhanced when combined with IL-2. In the present study, we investigated whether the combination of exogenous IL-2 and IL-18 alters airway hyperresponsiveness (AHR) and airway inflammation. Sensitized mice exposed to ovalbumin (OVA) challenge develo...

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Detalhes bibliográficos
Main Authors: Matsubara, Shigeki, Takeda, Katsuyuki, Kodama, Taku, Joetham, Anthony, Miyahara, Nobuaki, Koya, Toshiyuki, Swasey, Christina H., Okamoto, Masakazu, Dakhama, Azzeddine, Gelfand, Erwin W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899318/
https://ncbi.nlm.nih.gov/pubmed/17038663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2006-0231OC
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