Activation of naturally occurring lung CD4(+)CD25(+) regulatory T cells requires CD8 and MHC I interaction

Naturally occurring Foxp3(+)CD4(+)CD25(+) T cells (nTregs) isolated from lungs of naive mice regulate allergic airway hyperresponsiveness (AHR) and inflammation. Here, we demonstrate the critical requirement for engagement of MHC class I on CD4(+)CD25(+) T cells by CD8 for the functional activation...

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Hauptverfasser: Joetham, Anthony, Takeda, Katsuyuki, Miyahara, Nobuaki, Matsubara, Shigeki, Ohnishi, Hiroshi, Koya, Toshiyuki, Dakhama, Azzeddine, Gelfand, Erwin W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1986612/
https://ncbi.nlm.nih.gov/pubmed/17855564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706765104
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