Stable Expression of Recombinant Factor VIII in CHO Cells Using Methotrexate-Driven Transgene Amplification

Prophylaxis and treatment of inherited clotting disorder hemophilia A requires regular administration of factor VIII. Recombinant factor VIII, which is produced in CHO or BHK cells, is equivalent to the plasma-derived one and is prevalent in current clinical practice in developed countries. Developm...

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Main Authors: Orlova, N. A., Kovnir, S. V., Vorobiev, I. I., Yuriev, A.S., Gabibov, A.G., Vorobiev, A.I.
Format: Artigo
Sprog:Inglês
Udgivet: A.I. Gordeyev 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372988/
https://ncbi.nlm.nih.gov/pubmed/22708069
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