Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse, human glioblastomas in the mouse brain in vivo

Dysregulated metabolism is a hallmark of cancer cell lines, but little is known about the fate of glucose and other nutrients in tumors growing in their native microenvironment. To study tumor metabolism in vivo, we used an orthotopic mouse model of primary human glioblastoma (GBM). We infused (13)C...

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Hlavní autoři: Marin-Valencia, Isaac, Yang, Chendong, Mashimo, Tomoyuki, Cho, Steve, Baek, Hyeonman, Yang, Xiao-Li, Rajagopalan, Kartik N., Maddie, Melissa, Vemireddy, Vamsidhara, Zhao, Zhenze, Cai, Ling, Good, Levi, Tu, Benjamin P., Hatanpaa, Kimmo J., Mickey, Bruce E., Matés, José M., Pascual, Juan M., Maher, Elizabeth A., Malloy, Craig R., DeBerardinis, Ralph J., Bachoo, Robert M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372870/
https://ncbi.nlm.nih.gov/pubmed/22682223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.05.001
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