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Maternal loss of Ube3a produces an excitatory/inhibitory imbalance through neuron type-specific synaptic defects
Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of the maternally inherited allele of UBE3A. AS model mice, which carry a maternal Ube3a null mutation (Ube3a(m−/p+)), recapitulate major features of AS in humans, including enhanced seizure susceptibility. Excitatory neurotransm...
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| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372864/ https://ncbi.nlm.nih.gov/pubmed/22681684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.03.036 |
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