Loading...
Maternal loss of Ube3a produces an excitatory/inhibitory imbalance through neuron type-specific synaptic defects
Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of the maternally inherited allele of UBE3A. AS model mice, which carry a maternal Ube3a null mutation (Ube3a(m−/p+)), recapitulate major features of AS in humans, including enhanced seizure susceptibility. Excitatory neurotransm...
Na minha lista:
| Main Authors: | , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372864/ https://ncbi.nlm.nih.gov/pubmed/22681684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2012.03.036 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|