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Reversal of functional defects in highly differentiated young and old CD8 T cells by PDL blockade
Highly differentiated CD8(+) CD28(−) CD27(−) T cells have short telomeres, defective telomerase activity and reduced capacity for proliferation. In addition, these cells express increased levels of inhibitory receptors and display defective Akt(ser(473)) phosphorylation following activation. It is n...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372750/ https://ncbi.nlm.nih.gov/pubmed/22211948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2011.03550.x |
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