A trivalent recombinant Ad5 gag/pol/nef vaccine fails to protect rhesus macaques from infection or control virus replication after a limiting-dose heterologous SIV challenge

It has been suggested that poor immunogenicity may explain the lack of vaccine efficacy in preventing or controlling HIV infection in the Step trial. To investigate this issue we vaccinated eight Indian rhesus macaques with a trivalent replication-incompetent adenovirus serotype 5 vaccine expressing...

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Detalhes bibliográficos
Main Authors: Reynolds, Matthew R., Weiler, Andrea M., Piaskowski, Shari M., Piatak, Michael, Robertson, Henry T., Allison, David B., Bett, Andrew J., Casimiro, Danilo R., Shiver, John W., Wilson, Nancy A., Lifson, Jeffrey D., Koff, Wayne C., Watkins, David I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372643/
https://ncbi.nlm.nih.gov/pubmed/22569124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2012.04.082
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