Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques

Most simian immunodeficiency viruses use Nef to counteract the tetherin proteins of their nonhuman primate hosts. Nef also downmodulates cell-surface CD4 and MHC class I (MHC I) molecules and enhances viral infectivity by counteracting SERINC5. We previously demonstrated that tetherin antagonism by...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Tavakoli-Tameh, Aidin, Janaka, Sanath Kumar, Zarbock, Katie, O’Connor, Shelby, Crosno, Kristin, Capuano, Saverio, Uno, Hajime, Lifson, Jeffrey D., Evans, David T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190186/
https://ncbi.nlm.nih.gov/pubmed/32302364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008487
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