Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques

Most simian immunodeficiency viruses use Nef to counteract the tetherin proteins of their nonhuman primate hosts. Nef also downmodulates cell-surface CD4 and MHC class I (MHC I) molecules and enhances viral infectivity by counteracting SERINC5. We previously demonstrated that tetherin antagonism by...

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Vydáno v:PLoS Pathog
Hlavní autoři: Tavakoli-Tameh, Aidin, Janaka, Sanath Kumar, Zarbock, Katie, O’Connor, Shelby, Crosno, Kristin, Capuano, Saverio, Uno, Hajime, Lifson, Jeffrey D., Evans, David T.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190186/
https://ncbi.nlm.nih.gov/pubmed/32302364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008487
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