Loading...

Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques

Most simian immunodeficiency viruses use Nef to counteract the tetherin proteins of their nonhuman primate hosts. Nef also downmodulates cell-surface CD4 and MHC class I (MHC I) molecules and enhances viral infectivity by counteracting SERINC5. We previously demonstrated that tetherin antagonism by...

Full description

Saved in:
Bibliographic Details
Published in:PLoS Pathog
Main Authors: Tavakoli-Tameh, Aidin, Janaka, Sanath Kumar, Zarbock, Katie, O’Connor, Shelby, Crosno, Kristin, Capuano, Saverio, Uno, Hajime, Lifson, Jeffrey D., Evans, David T.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190186/
https://ncbi.nlm.nih.gov/pubmed/32302364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008487
Tags: Add Tag
No Tags, Be the first to tag this record!