Low-Dose Penile SIVmac251 Exposure of Rhesus Macaques Infected with Adenovirus Type 5 (Ad5) and Then Immunized with a Replication-Defective Ad5-Based SIV gag/pol/nef Vaccine Recapitulates the Results of the Phase IIb Step Trial of a Similar HIV-1 Vaccine

The Step Trial showed that the MRKAd5 HIV-1 subtype B Gag/Pol/Nef vaccine did not protect men from HIV infection or reduce setpoint plasma viral RNA (vRNA) levels but, unexpectedly, it did modestly enhance susceptibility to HIV infection in adenovirus type 5 (Ad5)-seropositive, uncircumcised men. As...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Qureshi, Huma, Ma, Zhong-Min, Huang, Ying, Hodge, Gregory, Thomas, Michael A., DiPasquale, Janet, DeSilva, Veronique, Fritts, Linda, Bett, Andrew J., Casimiro, Danilo R., Shiver, John W., Robert-Guroff, Marjorie, Robertson, Michael N., McChesney, Michael B., Gilbert, Peter B., Miller, Christopher J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2012
Pynciau:
Pathogenesis and Immunity
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302390/
https://ncbi.nlm.nih.gov/pubmed/22156519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06175-11
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