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ATM-dependent phosphorylation of the checkpoint clamp regulates repair pathways and maintains genomic stability
Upon genotoxic stress and during normal S phase, ATM phosphorylates the checkpoint clamp protein Rad9 in a manner that depends on Ser272. Ser272 is the only known ATM-dependent phosphorylation site in human Rad9. However, Ser272 phosphorylation is not required for survival or checkpoint activation a...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3372382/ https://ncbi.nlm.nih.gov/pubmed/22453082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.20161 |
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