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ATM- and ATR-Mediated Phosphorylation of XRCC3 Regulates DNA Double-Strand Break-Induced Checkpoint Activation and Repair

The RAD51 paralogs XRCC3 and RAD51C have been implicated in homologous recombination (HR) and DNA damage responses. However, the molecular mechanism(s) by which these paralogs regulate HR and DNA damage signaling remains obscure. Here, we show that an SQ motif serine 225 in XRCC3 is phosphorylated b...

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Bibliographische Detailangaben
Hauptverfasser: Somyajit, Kumar, Basavaraju, Shivakumar, Scully, Ralph, Nagaraju, Ganesh
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624173/
https://ncbi.nlm.nih.gov/pubmed/23438602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01521-12
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