Attenuation of Chikungunya Virus Vaccine Strain 181/Clone 25 Is Determined by Two Amino Acid Substitutions in the E2 Envelope Glycoprotein

Chikungunya virus (CHIKV) is the mosquito-borne alphavirus that is the etiologic agent of massive outbreaks of arthralgic febrile illness that recently affected millions of people in Africa and Asia. The only CHIKV vaccine that has been tested in humans, strain 181/clone 25, is a live-attenuated der...

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Detalles Bibliográficos
Main Authors: Gorchakov, Rodion, Wang, Eryu, Leal, Grace, Forrester, Naomi L., Plante, Kenneth, Rossi, Shannan L., Partidos, Charalambos D., Adams, A. Paige, Seymour, Robert L., Weger, James, Borland, Erin M., Sherman, Michael B., Powers, Ann M., Osorio, Jorge E., Weaver, Scott C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Vaccines and Antiviral Agents
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372191/
https://ncbi.nlm.nih.gov/pubmed/22457519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06449-11
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