Epidermal ADAM17 maintains the skin barrier by regulating EGFR ligand–dependent terminal keratinocyte differentiation

ADAM17 (a disintegrin and metalloproteinase 17) is ubiquitously expressed and cleaves membrane proteins, such as epidermal growth factor receptor (EGFR) ligands, l-selectin, and TNF, from the cell surface, thus regulating responses to tissue injury and inflammation. However, little is currently know...

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Autori principali: Franzke, Claus-Werner, Cobzaru, Cristina, Triantafyllopoulou, Antigoni, Löffek, Stefanie, Horiuchi, Keisuke, Threadgill, David W., Kurz, Thomas, van Rooijen, Nico, Bruckner-Tuderman, Leena, Blobel, Carl P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371728/
https://ncbi.nlm.nih.gov/pubmed/22565824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112258
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