A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

Chromosomal common fragile sites (CFSs) are unstable genomic regions that break under replication stress and are involved in structural variation. They frequently are sites of chromosomal rearrangements in cancer and of viral integration. However, CFSs are undercharacterized at the molecular level a...

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Bibliographic Details
Main Authors: Fungtammasan, Arkarachai, Walsh, Erin, Chiaromonte, Francesca, Eckert, Kristin A., Makova, Kateryna D.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2012
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371707/
https://ncbi.nlm.nih.gov/pubmed/22456607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.134395.111
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