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RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repair
Protein ubiquitylation and sumoylation play key roles in regulating cellular responses to DNA double-strand breaks (DSBs). Here, we show that human RNF4, a small ubiquitin-like modifier (SUMO)-targeted ubiquitin E3 ligase, is recruited to DSBs in a manner requiring its SUMO interaction motifs, the S...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3371407/ https://ncbi.nlm.nih.gov/pubmed/22661229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.188284.112 |
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