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α-Synuclein Induces Both Positive Mean Curvature and Negative Gaussian Curvature in Membranes

Using a combination of X-ray scattering, fluorescence correlation spectroscopy, coarse-grained molecular dynamics (MD) simulations and potential of mean force calculations, we have explored the membrane remodeling effects of monomeric α-synuclein (αS). Our initial findings from multiple approaches a...

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Main Authors: Braun, Anthony R., Sevcsik, Eva, Chin, Pamela, Rhoades, Elizabeth, Tristram-Nagle, Stephanie, Sachs, Jonathan N.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371389/
https://ncbi.nlm.nih.gov/pubmed/22211521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja208316h
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