DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau

Tau aggregation and amyloidogenesis are common hallmarks for neurodegenerative disorders called tauopathies. The molecular chaperone network constitutes the cellular defense against insults such as tau aggregation. However, chaperone effects on tau are dichotomous. Loss of tau’s microtubule-binding...

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Main Authors: Abisambra, Jose F., Jinwal, Umesh K., Suntharalingam, Amirthaa, Arulselvam, Karthik, Brady, Sarah, Cockman, Mattew, Jin, Ying, Zhang, Bo, Dickey, Chad A.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371317/
https://ncbi.nlm.nih.gov/pubmed/22343013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.02.003
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