DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau

Tau aggregation and amyloidogenesis are common hallmarks for neurodegenerative disorders called tauopathies. The molecular chaperone network constitutes the cellular defense against insults such as tau aggregation. However, chaperone effects on tau are dichotomous. Loss of tau’s microtubule-binding...

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Main Authors: Abisambra, Jose F., Jinwal, Umesh K., Suntharalingam, Amirthaa, Arulselvam, Karthik, Brady, Sarah, Cockman, Mattew, Jin, Ying, Zhang, Bo, Dickey, Chad A.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371317/
https://ncbi.nlm.nih.gov/pubmed/22343013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.02.003
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