APOBEC3G Expression and Hypermutation Are Inversely Associated With Human Immunodeficiency Virus Type 1 (HIV-1) Burden In Vivo

APOBEC3G (A3G) and APOBEC3F (A3F) reduce Vif-negative HIV-1 provirus formation and cause disabling provirus G-to-A hypermutation in vitro. However, evidence conflicts about whether they negatively impact Vif-positive HIV-1, or only enhance virus genetic diversity, in vivo. We studied peripheral bloo...

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Autors principals: Kourteva, Yordanka, De Pasquale, MariaPia, Allos, Tara, McMunn, Chara, D’Aquila, Richard T.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371094/
https://ncbi.nlm.nih.gov/pubmed/22579353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2012.03.018
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