Phosphorylation of p65(RelA) on Ser(547) by ATM Represses NF-κB-Dependent Transcription of Specific Genes after Genotoxic Stress

The NF-κB pathway is involved in immune and inflammation responses, proliferation, differentiation and cell death or survival. It is activated by many external stimuli including genotoxic stress. DNA double-strand breaks activate NF-κB in an ATM-dependent manner. In this manuscript, a direct interac...

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Bibliographic Details
Main Authors: Sabatel, Hélène, Di Valentin, Emmanuel, Gloire, Geoffrey, Dequiedt, Franck, Piette, Jacques, Habraken, Yvette
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3371017/
https://ncbi.nlm.nih.gov/pubmed/22715377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0038246
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