ASPP2 suppresses squamous cell carcinoma via RelA/p65–mediated repression of p63

Squamous cell carcinoma (SCC) is highly malignant and refractory to therapy. The majority of existing mouse SCC models involve multiple gene mutations. Very few mouse models of spontaneous SCC have been generated by a single gene deletion. Here we report a haploinsufficient SCC mouse model in which...

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Detalhes bibliográficos
Main Authors: Tordella, Luca, Koch, Sofia, Salter, Victoria, Pagotto, Anna, Doondeea, Jessica B., Feller, Stephan M., Ratnayaka, Indrika, Zhong, Shan, Goldin, Robert D., Lozano, Guillermina, McKeon, Frank D., Tavassoli, Mahvash, Fritzsche, Florian, Huber, Gerhard F., Rössle, Matthias, Moch, Holger, Lu, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816480/
https://ncbi.nlm.nih.gov/pubmed/24127607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1309362110
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