Pharmacokinetic Comparison of Two Piperaquine-Containing Artemisinin Combination Therapies in Papua New Guinean Children with Uncomplicated Malaria

Pharmacokinetic differences between piperaquine (PQ) base and PQ tetraphosphate were investigated in 34 Papua New Guinean children aged 5 to 10 years treated for uncomplicated malaria with artemisinin-PQ (ART-PQ) base or dihydroartemisinin-PQ (DHA-PQ) tetraphosphate. Twelve children received ART-PQ...

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Autors principals: Salman, Sam, Page-Sharp, Madhu, Batty, Kevin T., Kose, Kaye, Griffin, Susan, Siba, Peter M., Ilett, Kenneth F., Mueller, Ivo, Davis, Timothy M. E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370744/
https://ncbi.nlm.nih.gov/pubmed/22470119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06232-11
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