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Dosing Regimen Matters: the Importance of Early Intervention and Rapid Attainment of the Pharmacokinetic/Pharmacodynamic Target

To date, the majority of pharmacokinetic/pharmacodynamic (PK/PD) discussions have focused on PK/PD relationships evaluated at steady-state drug concentrations. However, a concern with reliance upon steady-state drug concentrations is that it ignores events occurring while the pathogen is exposed to...

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Detalhes bibliográficos
Main Authors: Martinez, Marilyn N., Papich, Mark G., Drusano, George L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370717/
https://ncbi.nlm.nih.gov/pubmed/22371890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05360-11
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