Pharmacokinetic/pharmacodynamic modeling for the determination of a cimicoxib dosing regimen in the dog

BACKGROUND: Cimicoxib is a new coxib anti-inflammatory drug for use in the dog. To determine a preclinical dosage regimen for cimicoxib in dog, a reversible model of kaolin–induced paw inflammation was used. Dosage regimens were established using pharmacokinetic/pharmacodynamic (PK/PD) modeling appr...

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Bibliographic Details
Main Authors: Jeunesse, Elisabeth C, Schneider, Marc, Woehrle, Frederique, Faucher, Mathieu, Lefebvre, Herve P, Toutain, Pierre-Louis
Format: Artigo
Language:Inglês
Published: BioMed Central 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3892053/
https://ncbi.nlm.nih.gov/pubmed/24330630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1746-6148-9-250
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