Increased myofilament Ca(2+) sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

Hypertrophic cardiomyopathy (HCM) is frequently caused by mutations in MYBPC3 encoding cardiac myosin-binding protein C (cMyBP-C). The mechanisms leading from gene mutations to the HCM phenotype remain incompletely understood, partially because current mouse models of HCM do not faithfully reflect t...

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Hauptverfasser: Fraysse, Bodvaël, Weinberger, Florian, Bardswell, Sonya C., Cuello, Friederike, Vignier, Nicolas, Geertz, Birgit, Starbatty, Jutta, Krämer, Elisabeth, Coirault, Catherine, Eschenhagen, Thomas, Kentish, Jonathan C., Avkiran, Metin, Carrier, Lucie
Format: Artigo
Sprache:Inglês
Veröffentlicht: Academic Press 2012
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370652/
https://ncbi.nlm.nih.gov/pubmed/22465693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2012.03.009
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