Distinct Sarcomeric Substrates Are Responsible for Protein Kinase D-mediated Regulation of Cardiac Myofilament Ca(2+) Sensitivity and Cross-bridge Cycling

Protein kinase D (PKD), a serine/threonine kinase with emerging cardiovascular functions, phosphorylates cardiac troponin I (cTnI) at Ser(22)/Ser(23), reduces myofilament Ca(2+) sensitivity, and accelerates cross-bridge cycle kinetics. Whether PKD regulates cardiac myofilament function entirely thro...

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Main Authors: Bardswell, Sonya C., Cuello, Friederike, Rowland, Alexandra J., Sadayappan, Sakthivel, Robbins, Jeffrey, Gautel, Mathias, Walker, Jeffery W., Kentish, Jonathan C., Avkiran, Metin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2010
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2820795/
https://ncbi.nlm.nih.gov/pubmed/20018870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.066456
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