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Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma

To gain more insight into the role of chromosomal instability (CIN), the cytogenetic hallmark of most solid tumors, we performed fluorescence in situ hybridization (FISH) on interphase nuclei of cytological specimens enabling the correct detection of chromosome copies in intact tumor cells of 18 wel...

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Main Authors: Wilkens, Ludwig, Flemming, Peer, Gebel, Michael, Bleck, Joerg, Terkamp, Christof, Wingen, Luzie, Kreipe, Hans, Schlegelberger, Brigitte
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC337049/
https://ncbi.nlm.nih.gov/pubmed/14745031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305817101
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