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Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma

To gain more insight into the role of chromosomal instability (CIN), the cytogenetic hallmark of most solid tumors, we performed fluorescence in situ hybridization (FISH) on interphase nuclei of cytological specimens enabling the correct detection of chromosome copies in intact tumor cells of 18 wel...

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Detalles Bibliográficos
Main Authors: Wilkens, Ludwig, Flemming, Peer, Gebel, Michael, Bleck, Joerg, Terkamp, Christof, Wingen, Luzie, Kreipe, Hans, Schlegelberger, Brigitte
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC337049/
https://ncbi.nlm.nih.gov/pubmed/14745031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305817101
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