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Boveri revisited: Chromosomal instability, aneuploidy and tumorigenesis
The mitotic checkpoint guards against chromosome missegregation and the production of aneuploid daughter cells. Aneuploidy is a common characteristic of tumor cells and has been proposed for over a century to drive tumor progression. However, recent evidence has revealed that although aneuploidy can...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3154738/ https://ncbi.nlm.nih.gov/pubmed/19546858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrm2718 |
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