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Caspase cleavage of Bim(EL) triggers a positive feedback amplification of apoptotic signaling
Members of the Bcl-2 protein family that share only the Bcl-2 homology 3 (BH3) domain are known mostly as sentinels for apoptotic stimuli and initiators of apoptosis. One BH3-only protein, Bim, is the major physiological antagonist of the prosurvival proteins in B and T lymphocytes. It is required f...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC337036/ https://ncbi.nlm.nih.gov/pubmed/14732682 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308050100 |
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