Caspase-2 Cleavage of BID Is a Critical Apoptotic Signal Downstream of Endoplasmic Reticulum Stress

The accumulation of misfolded proteins stresses the endoplasmic reticulum (ER) and triggers cell death through activation of the multidomain proapoptotic BCL-2 proteins BAX and BAK at the outer mitochondrial membrane. The signaling events that connect ER stress with the mitochondrial apoptotic machi...

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Hlavní autoři: Upton, John-Paul, Austgen, Kathryn, Nishino, Mari, Coakley, Kristen M., Hagen, Andrew, Han, Dan, Papa, Feroz R., Oakes, Scott A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2423129/
https://ncbi.nlm.nih.gov/pubmed/18426910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00013-08
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