Artesunate/dihydroartemisinin pharmacokinetics in acute falciparum malaria in pregnancy: absorption, bioavailability, disposition and disease effects

AIM: To determine if reported lower plasma concentrations of artemisinin derivatives for malaria in pregnancy result from reduced oral bioavailability, expanded volume of distribution or increased clearance. METHODS: In a sequentially assigned crossover treatment study, pregnant women with uncomplic...

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Main Authors: McGready, Rose, Phyo, Aung Pyae, Rijken, Marcus J, Tarning, Joel, Lindegardh, Niklas, Hanpithakpon, Warunee, Than, Hla Hla, Hlaing, Nathar, Zin, Naw Thida, Singhasivanon, Pratap, White, Nicholas J, Nosten, François
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2012
Teme:
Drugs in Pregnancy and Lactation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370352/
https://ncbi.nlm.nih.gov/pubmed/21950338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2011.04103.x
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