Specific Domains in Yeast Translation Initiation Factor eIF4G Strongly Bias RNA Unwinding Activity of the eIF4F Complex toward Duplexes with 5′-Overhangs

During eukaryotic translation initiation, the 43 S ribosomal pre-initiation complex is recruited to the 5′-end of an mRNA through its interaction with the 7-methylguanosine cap, and it subsequently scans along the mRNA to locate the start codon. Both mRNA recruitment and scanning require the removal...

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Bibliografiske detaljer
Main Authors:	Rajagopal, Vaishnavi, Park, Eun-Hee, Hinnebusch, Alan G., Lorsch, Jon R.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Biochemistry and Molecular Biology 2012
Fag:	Protein Synthesis and Degradation
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3370212/ https://ncbi.nlm.nih.gov/pubmed/22467875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347278
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Specific Domains in Yeast Translation Initiation Factor eIF4G Strongly Bias RNA Unwinding Activity of the eIF4F Complex toward Duplexes with 5′-Overhangs

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