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Specific Domains in Yeast Translation Initiation Factor eIF4G Strongly Bias RNA Unwinding Activity of the eIF4F Complex toward Duplexes with 5′-Overhangs
During eukaryotic translation initiation, the 43 S ribosomal pre-initiation complex is recruited to the 5′-end of an mRNA through its interaction with the 7-methylguanosine cap, and it subsequently scans along the mRNA to locate the start codon. Both mRNA recruitment and scanning require the removal...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3370212/ https://ncbi.nlm.nih.gov/pubmed/22467875 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347278 |
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