FoxO1 Inhibits Sterol Regulatory Element-binding Protein-1c (SREBP-1c) Gene Expression via Transcription Factors Sp1 and SREBP-1c

Induction of lipogenesis in response to insulin is critically dependent on the transcription factor, sterol regulatory element-binding protein-1c (SREBP-1c). FoxO1, a forkhead box class-O transcription factor, is an important mediator of insulin action, but its role in the regulation of lipid metabo...

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Bibliographic Details
Main Authors: Deng, Xiong, Zhang, Wenwei, O-Sullivan, InSug, Williams, J. Bradley, Dong, Qingming, Park, Edwards A., Raghow, Rajendra, Unterman, Terry G., Elam, Marshall B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370196/
https://ncbi.nlm.nih.gov/pubmed/22511764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347211
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