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Aminopeptidase Substrate Preference Impacts HIV Epitope Presentation and Predicts Immune Escape Patterns in HIV-infected Persons

Viruses evade immune detection partly through immune-associated mutations. Analyses of HIV sequences derived from infected persons have identified numerous examples of HLA-associated mutations within or adjacent T cell epitopes, but the potential impact of most mutations on epitope production and pr...

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Detalhes bibliográficos
Main Authors: Zhang, Shao Chong, Martin, Eric, Shimada, Mariko, Godfrey, Sasha Blue, Fricke, Jennifer, Locastro, Shirley, Lai, Nicole Y., Liebesny, Paul, Carlson, Jonathan M., Brumme, Chanson J., Ogbechie, Oluwatobi Awele, Chen, Huabiao, Walker, Bruce D., Brumme, Zabrina L., Kavanagh, Daniel G., Le Gall, Sylvie
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370117/
https://ncbi.nlm.nih.gov/pubmed/22586036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200219
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