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Point Mutations in Aβ Induce Polymorphic Aggregates at Liquid/Solid Interfaces

[Image: see text] A pathological hallmark of Alzheimer’s disease (AD), a late onset neurodegenerative disease, is the development of neuritic amyloid plaques, composed predominantly of aggregates of the β-amyloid (Aβ) peptide. It has been demonstrated that Aβ can aggregate into a variety of polymorp...

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Detalhes bibliográficos
Main Authors: Yates, Elizabeth A., Cucco, Elena M., Legleiter, Justin
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2011
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369758/
https://ncbi.nlm.nih.gov/pubmed/22778873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200001k
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