A critical role for endoglin in the emergence of blood during embryonic development

Much remains unknown about the signals that induce early mesoderm to initiate hematopoietic differentiation. Here, we show that endoglin (Eng), a receptor for the TGFβ superfamily, identifies all cells with hematopoietic fate in the early embryo. These arise in an Eng(+)Flk1(+) mesodermal precursor...

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Detalles Bibliográficos
Autores principales: Borges, Luciene, Iacovino, Michelina, Mayerhofer, Timothy, Koyano-Nakagawa, Naoko, Baik, June, Garry, Daniel J., Kyba, Michael, Letarte, Michelle, Perlingeiro, Rita C. R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2012
Materias:
Hematopoiesis and Stem Cells
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3369678/
https://ncbi.nlm.nih.gov/pubmed/22535663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-391896
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